MySims hands-on at Gamespot.
'Though similar in concept to its counterpart on the Nintendo Wii, MySims for the Nintendo DS has a feel all its own thanks to the console's dual-screen presentation, stylus and touch-screen interface, and an urban-renewal focus that has more to do with redecoration than from-the-ground-up creation. We had a chance to see and play the DS version of MySims at EA's hotel space at E3 2007.
As in the Wii version of the game, you're still tasked with reinvigorating a run-down town full of NPC Sims who you will interact with and get tasks from. In MySims for the DS, however, you'll be living in a resort town, and the goal is to bring both new shop owners and plenty of money-spending tourists into town in order to progress in the game. Each area of town has at least one citizen that can perform special abilities, such as a tailor you can visit in order to customize your Sim's clothing."
Full Source: Gamespot